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  • Writer's pictureRicardo Franco II

Endocannabinoid system and cannabidiol

Updated: Oct 26, 2022

Endocannabinoids and their receptors are found throughout the body, in cell membranes in the brain, organs, connective tissues, glands, and immune cells.

In each part of the organism the system performs different tasks.

However, the purpose is always the same: the stabilization of the internal environment, regardless of external variations, that is, homeostasis.

The endocannabinoid system is also found at the intersections of various systems, allowing for communication and coordination between cells.

When cannabinoid receptors are stimulated, a variety of physiological mechanisms take place.

The system is responsible for regulating physiological processes such as appetite, pain, inflammation, thermoregulation, intraocular pressure, sensation, muscle control, energy balance, metabolism, sleep quality, stress response, motivation/reward, mood and memory.

So far, researchers have identified two cannabinoid receptors.

The first is CB1, which is found predominantly in the nervous system, connective tissue, gonads, glands and organs.

CB2 receptors are found in the immune system and its structures.

Some cells contain both CB1 and CB2 receptors, each linked to different functions.

Although our bodies are able to manufacture their own cannabinoids, the endocannabinoid system can be supplemented by exogenous phytocannabinoids found in plants such as cannabis, echinacea and flaxseed.

Endocannabinoid system and cannabidiol

Cannabidiol interacts with the endocannabinoid system through the CB2 receptor, offering the desired beneficial effects for conditions such as epilepsy, Parkinson's, pain, cancer and multiple sclerosis.

The Bulgarian chemist based in Israel, Raphael Mechoulam, rediscovered the historical use of the substance for the treatment of convulsive pathologies, schizophrenia, post-traumatic stress and also its impact on other functions that manage human health, such as the speed in the connection between a mother and a baby.

It is for the body to remain balanced that the endocannabinoid system exists.


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